Isoquinoline Alkaloids and Homoisoflavonoids from Drimiopsis barteri Bak and D. burkei Bak
نویسندگان
چکیده
منابع مشابه
Cancer chemoresistance and BAK
Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upon cell survival. Interestingly though, many cancers have intact apoptotic machinery where mutation rates of key regulators is very low the BCL-2 fa...
متن کاملColloquium Paper : Bak and Paczuski
Complexity originates from the tendency of large dynamical systems to organize themselves into a critical state, with avalanches or "punctuations" of all sizes. In the critical state, events which would otherwise be uncoupled become correlated. The apparent, historical corntingency in many sciences, including geology, biology, and economics, finds a natural interpretation as a self-organized cr...
متن کاملA BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway
Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic reticulum (ER) stress leads to apoptosis through the upregulation of a subset of pro-apoptotic BH3-only proteins, activating BAX and BAK at the mitochondria. Here we provide eviden...
متن کاملBak - Sneppen Model
R. Cafiero, P. De Los Rios, A. Valleriani, and J. L. Vega 1 P.M.M.H., Ecole Supérieure de Physique et de chimie Industrielles, 10, rue Vaquelin, 75231 Paris, France. 2 Institut de Physique Theorique, Université de Fribourg, CH-1700 Fribourg, Switzerland. 3 Max-Planck-Institute of Colloids and Interfaces Theory Division Kantstrasse 55, D-14513 Teltow-Seehof, Germany 4 BANCOTEC GmbH, Calwerstraße...
متن کاملKey role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine.
Microtubule inhibitors such as vinblastine cause mitotic arrest and subsequent apoptosis through the intrinsic mitochondrial pathway. However, although Bcl-2 family proteins have been implicated as distal mediators, their precise role is largely unknown. In this study, we investigated the role of Bak in vinblastine-induced apoptosis. Bak was mainly monomeric in untreated KB-3 cells, and multime...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2008
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x0800300518